Extracellular Thimet Oligopeptidase is Carried by Cell Membrane Microvesicles of Human Prostate Cancer Cells
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چکیده
Extracellular Thimet Oligopeptidase is Carried by Cell Membrane Microvesicles of Human Prostate Cancer Cells
منابع مشابه
Regulation of levels and localization of thimet oligopeptidase in prostate cancer cells by Î2-estradiol
DeFries, Christa, "Regulation of levels and localization of thimet oligopeptidase in prostate cancer cells by β-estradiol" (2013). Honors Thesis Collection. Paper 161. Abstract The enzyme thimet oligopeptidease (TOP) catalyzes the hydrolysis of gonadotropin-releasing hormone (GnRH) in vitro, and evidence suggests that TOP is the primary enzyme responsible for GnRH hydrolysis in vivo, as well. I...
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We have purified human thimet oligopeptidase to homogeneity from erythrocytes, and compared it with the enzyme from rat testis and chicken liver. An antiserum raised against rat thimet oligopeptidase also recognized the human and chicken enzymes, suggesting that the structure of the enzyme has been strongly conserved in evolution. Consistent with this, the properties of the human enzyme were ve...
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